Elliott S. Goldstein
Molecular and Developmental Genetics
The research program is centered on understanding control of gene expression. The model system employed is the oncogenes jun and fos in the fly Drosophila melanogaster. The jun gene product, the Jun protein, is most commonly found associated with the fos gene product, the Fos protein. The Jun/Fos heterodimer, called AP-1, is a gene regulator responsible for controlling the activities of a number of genes, either as a positive regulator or as a negative regulator. Since Jun and Fos are used in many gene networks, together and separately, their genes are under the control of numerous regulators. AP-1 itself is modulated posttranscriptionally through signal transduction pathways. Jun and Fos are involved in a number of important events including developmental processes and most recently, learning and memory.
Research is now focused on the analysis of the control region of the fos gene and the determination of how it is regulated.
Selected Publications
Hudson, S. G. and Goldstein, E. S. (2006) "Characterization of the gene structure and embryonic expression pattern of the nested Drosophila melanogaster genes kayak and fig " manuscript in preparation
Rousseau, E. and Goldstein, E.S. (2001) "The Gene Structure of the Drosophila melanogaster Homolog of the Human Proto-oncogene fos". Gene 272, 315-322.
Goldstein, E.S., Treadway, S.L., Stephenson, A.E., Gramstad, G.D., Keilty, A., Kirsch, L., Imperial, M., Guest, S., Hudson, S.G., LeBell, A.A., O'Day, M., Duncan, C., Tallman, M., Cattelino, A., and Lim, J. (2001). "A Genetic Analysis of the 2R 46 C-F Region Containing the Drosophila Melanogaster Homolog at the jun proto-oncogene" Molecular Genetics and Genomics 266, 695-700
Xia, X. and E.S. Goldstein (1999). The Response of Djun and Dfos Transcription to the Signal Transduction Pathways in Cultured Cells of Drosophila Melanogaster. Molecular Biology Reports 26, 147-157.
Carney, G.E., Wade, A.A., Sapra, R., Goldstein, E.S. and Bender, M. (1997). "DHR3, an ecdysone-inducible early-late gene encoding a Drosophila nuclear receptor, is required for embryogenesis." PNAS 94, 12024-12029.
Hou, S.X., Goldstein, E.S., and Perrimon, N. (1997). Drosophila jun relays the JNK signal transduction pathway to the DPP signal transduction pathway in regulating epithelial cell sheet movement. Genes and Development 11:1728-1737.