Philip W. Hedrick
Conservation and Evolutionary Genetics
My research focuses on the conservation genetics of endangered species and the genetic bases of evolutionary processes. Recent projects in my laboratory have examined the effects of inbreeding and outbreeding on fitness-related characters in Sonoran topminnows, Mexican and red wolves, and bighorn sheep. Current projects in the laboratory examine patterns of variation and factors affecting variability at major histocompatibility complex (MHC) and microsatellite loci. The MHC, whose genes are involved in immune response, are the most polymorphic loci known in many vertebrates. MHC and microsatellite variation have been examined in the Gila topminnows, desert bighorn sheep, Arabian oryx, and winter-run chinook salmon. I am also interested in theoretical research on the maintenance of genetic variation and inbreeding depression.
Selected Publications
Hedrick, P.W. 2005. "Genetic restoration": a more comprehensive perspective than "genetic rescue." Trends Ecol. Evol . 20: 109.
Hedrick, P. W., and L. Waits. 2005. What ancient DNA tells us. Heredity 94: 463-464.
Hedrick, P. W. 2005. Large variance in reproductive success and the N e / N ratio. Evolution 59:1596-1599.
Hedrick, P. W. 2005. A standardized genetic differentiation measure. Evolution 59: 1633-1638.
Hurt, C. R., M. Farzin, and P. W. Hedrick. 2005. Premating, not postmating, barriers drive genetic dynamics in experimental hybrid populations of the endangered Sonoran topminnow. Genetics 171:655-662.
Hedrick, P. W. 2004. Recent developments in conservation genetics. Fores. Ecol. Manag . 197:3-19.
Hedrick, P. W. 2004. Foxy MHC selection story. Heredity 93:237-238.
Hurt, C., and P. W. Hedrick. 2004. Conservation genetics in aquatic species. Aquatic Sciences 66:402-413.
Hedrick, P. W. 2004. Conservation biology: The impact of population biology and a current perspective, p. 347-365. In The Evolution of Population Biology Modern Synthesis . R. Singh and M Uyenoyama (eds.). Cambridge Univ. Press, Cambridge.
Weaver, R. F., and P. W. Hedrick. 2004. Heredity, p. 200-210. World Book Encyclopedia , Volume 9 (H). World Book Inc., Chicago.
Hedrick, P. W. 2004. Neutral, detrimental, and adaptive genetic variation in conservation genetics (in press). In Conservation Genetics in the Age of Genomics . G. Amato, O. Ryder, H. Rosenbaum, and R. DeSalle (eds.). Columbia Univ. Press, New York.
Hedrick, P. W. 2004. Estimation of relative fitnesses from relative risk data and the predicted future of hemoglobin alleles S and C . J. Evol. Biol. 17:221-224.
Hurt, C., S. Stears-Ellis, K. Hughes, and P. W. Hedrick. 2004. Mating behavior in the endangered Sonoran topminnow: speciation in action. Anim. Behav . 67:343-351.
Hedrick, P. W. 2004. Comment on Parasite Selection for Immunogenetic Optimality. Science 303:957a.