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Ian Hogue

Assistant Professor
Faculty
TEMPE Campus
Mailcode
7501
Assistant Professor
Faculty
TEMPE Campus
Mailcode
7501

Biography

Ian Hogue is an assistant professor in the Biodesign Center for Immunotherapy, Vaccines and Virotherapy and the School of Life Sciences at Arizona State University.

He earned a B.A. in molecular and cell biology at the University of California, Berkeley, where he performed undergraduate research on baculoviruses and worked as a laboratory technician studying alphavirus vaccine vectors at Chiron Corporation. He worked as a laboratory technician at University of Texas Southwestern Medical Center studying HIV-1 latency. He then earned his Ph.D. in microbiology and immunology at the University of Michigan, studying HIV-1 assembly. He then completed postdoctoral training at Princeton University, studying alpha herpesvirus egress and spread.

Professor Hogue’s research focuses on neurovirology, the molecular and cell biology of viruses in the nervous system. Specifically, his laboratory uses specialized live-cell fluorescence microscopy methods, cryo electron microscopy structural biology methods, and primary neuron cell culture methods to study how alpha herpesviruses interact with the molecular and cell biology of neurons.

Google Scholar

Publications

Hogue IB, Ambrosini AE, Deshmukh N, Berry MJ, Enquist LW. Alpha Herpesvirus Egress and Spread from Neurons Uses Constitutive Secretory Mechanisms and Does Not Depend on Action Potential Firing. In preparation.

Hogue IB, Card JP, Rinaman L, Staniszewska Goraczniak H, Enquist LW. Characterization of the neuroinvasive profile of a pseudorabies virus recombinant expressing the mTurquoise2 reporter in single and multiple injection experiments. J Neurosci Methods, 308:228-239, 2018.

Chen H, Bartee M, Yaron J, Liu L, Zhang L, Zheng D, Hogue I, Bullard W, Tibbets S, Lucas A. Mouse Gamma Herpesvirus MHV-68 Induces Severe Gastrointestinal (GI) Dilatation in Interferon Gamma Receptor-Deficient Mice (IFNγR−/−) That Is Blocked by Interleukin-10. Viruses, 10(10):518, 2018.

Hogue IB, Jean J, Scherer J, Enquist LW. A Functional Carboxy-Terminal Fluorescent Protein Fusion to Pseudorabies Virus Small Capsid Protein VP26. J Virology, 92(1):e01193-17, 2018.

Koyuncu OO, MacGibeny MA, Hogue IB, Enquist LW. Compartmented neuronal cultures reveal two distinct mechanisms for alpha herpesvirus escape from genome silencing. PLOS Pathogens, 13(10):e1006608, 2017.

Hogue IB, Scherer J, Enquist LW. Exocytosis of Alphaherpesvirus Virions, Light Particles, and Glycoproteins Uses Constitutive Secretory Mechanisms. mBio, 7(3): e00820-16, 2016.

Johnson BN, Lancaster KZ, Hogue IB, Meng F, Kong YL, Enquist LW, McAlpine, MC. 3D Printed Nervous System on a Chip. Lab on a Chip, 16(8):1393-1400, 2015. Featured in: The Royal Society of Chemistry’s Lab on a Chip 3D Printing Collection, 2016.

Bosse JB, Tanneti NS, Hogue IB, Enquist LW. Open LED Illuminator: A simple and inexpensive LED illuminator for fast multicolor particle tracking in neurons. PLOS One, 10(11):e0143547, 2015.

Hogue IB, Bosse JB, Engel EA, Scherer J, Hu J-R, del Rio T, Enquist LW. Fluorescent Protein Approaches in Alpha Herpesvirus Research. Viruses, 7:5933-5961, 2015.

Bosse JB, Hogue IB, Feric M, Thiberge SY, Sodeik B, Brangwynne CP, Enquist LW. Remodeling nuclear architecture allows efficient transport of herpesvirus capsids by diffusion. PNAS, 112(42):E5725-E5733, 2015.

Hogue IB, Bosse JB, Hu J-R, Thiberge SY, Enquist LW. Cellular Mechanisms of Alpha Herpesvirus Egress: Live Cell Fluorescence Microscopy of Pseudorabies Virus Exocytosis. PLOS Pathogens, 10(12):e1004535, 2014.

Nguyen TD, Hogue IB, Cung K, Purohit PK, McAlpine MC. Tension induced neurite growth in microfluidic channels. Lab on a Chip, 13(18):3735-3740, 2013.

Sun XR, Badura A, Pacheco DA, Lynch LA, Schneider ER, Taylor MP, Hogue IB, Enquist LW, Murthy M, Wang SS-H. Fast GCaMPs for improved tracking of neuronal activity. Nature Communications, 4:2170, 2013.

Koyuncu OO, Hogue IB, Enquist LW. Virus Infections in the Nervous System. Cell Host & Microbe, 13(4):379-93, 2013.

Hogue IB, Llewellyn GN, Ono A. Dynamic Association between HIV-1 Gag and Membrane Domains. Molecular Biology International, 2012.

Hogue IB, Grover JR, Soheilian F, Nagashima K, Ono A. Gag induces the coalescence of clustered lipid rafts and tetraspanin-enriched microdomains at HIV-1 assembly sites on the plasma membrane. J Virology, 85(19):9749-66, 2011.

Llewellyn GN, Hogue IB, Grover JR, Ono A. Nucleocapsid promotes localization of HIV-1 Gag to uropods that participate in virological synapses between T Cells. PLOS Pathogens, 6(10):e1001167, 2010.

Hogue IB, Hoppe A, Ono A. Quantitative fluorescence resonance energy transfer microscopy analysis of the human immunodeficiency virus type 1 Gag-Gag interaction: relative contributions of the CA and NC domains and membrane binding. J Virology, 83(14):7322-36, 2009.

Bauer AL, Hogue IB, Marino S, Kirschner DE. The Effects of HIV-1 Infection on Latent Tuberculosis. Mathematical Modelling of Natural Phenomena, 3(7):229, 2008.

Marino S, Hogue IB, Ray CJ, Kirschner DE. A methodology for performing global uncertainty and sensitivity analysis in systems biology. J Theoretical Biology, 254(1):178-96, 2008.

Hogue IB, Bajaria SH, Fallert BA, Qin S, Reinhart TA, Kirschner DE. The dual role of dendritic cells in the immune response to human immunodeficiency virus type 1 infection. J General Virology, 89(9):2228-2239, 2008. Featured in: The Society for General Microbiology’s Microbiology Today, November 2008.

Chukkapalli V, Hogue IB, Boyko V, Hu WS, Ono A. Interaction between Gag matrix domain and phosphatidylinositol-(4,5)-bisphosphate is essential for efficient Gag-membrane binding. J Virology, 82(5):2405-17, 2008.

Lehrman G, Hogue IB, Palmer S, Jennings C, Spina CA, Wiegand A, Landay AL, Coombs RW, Richman DD, Mellors JW, Coffin JM, Bosch RJ, Margolis DM. Depletion of latent HIV-1 infection in vivo: a proof-of-concept study. Lancet, 366(9485):549-55, 2005.

Courses

Summer 2020
Course Number Course Title
BDE 792 Research
Spring 2020
Course Number Course Title
MCB 494 Special Topics
MIC 494 Special Topics
NEU 494 Special Topics
MBB 494 Special Topics
BIO 494 Special Topics
MIC 495 Undergraduate Research
BIO 495 Undergraduate Research
MIC 498 Pro-Seminar
MIC 590 Reading and Conference
MIC 591 Seminar
NEU 591 Seminar
MCB 591 Seminar
MBB 591 Seminar
BIO 591 Seminar
MIC 791 Seminar
BDE 792 Research
BDE 799 Dissertation
Fall 2019
Course Number Course Title
MIC 495 Undergraduate Research
MIC 498 Pro-Seminar
MIC 591 Seminar
MIC 791 Seminar
Spring 2019
Course Number Course Title
MCB 494 Special Topics
MIC 494 Special Topics
NEU 494 Special Topics
MBB 494 Special Topics
BIO 494 Special Topics
MIC 495 Undergraduate Research
BIO 495 Undergraduate Research
MIC 498 Pro-Seminar
MIC 590 Reading and Conference
MIC 591 Seminar
NEU 591 Seminar
MCB 591 Seminar
MBB 591 Seminar
BIO 591 Seminar
MIC 791 Seminar
BDE 792 Research
BDE 799 Dissertation
Fall 2018
Course Number Course Title
MIC 498 Pro-Seminar
MIC 590 Reading and Conference
MIC 591 Seminar
MIC 791 Seminar
Spring 2018
Course Number Course Title
BIO 494 Special Topics
MCB 494 Special Topics
NEU 494 Special Topics
MIC 494 Special Topics
BIO 495 Undergraduate Research
NEU 591 Seminar
MCB 591 Seminar
BIO 591 Seminar
MIC 591 Seminar
MIC 791 Seminar

Expertise Areas