Jason Newbern

ISTB1 Rm 320
Arizona State University
Tempe
Asst Professor
Faculty
TEMPE Campus
Mailcode
4501

Biography

Jason Newbern's research is centered on developmental neuroscience. His laboratory studies the biochemical mechanisms that direct the formation of the brain and spinal cord. He uses genetic, cellular, and molecular techniques to investigate the development of neurons and glia in the nervous system.

Professor Newbern's team is also interested in a protein called "ERK/MAP kinase." The neurodevelopmental syndromes — Neurofibromatosis Type 1, Noonan-, and CFC-Syndrome — are caused by mutations in regulators of this protein. Abnormal activation of this protein may also be involved in schizophrenia and autism spectrum disorders.  The laboratory is currently studying precisely how ERK/MAP kinase controls the formation of neural circuits in the brain. The team is also studying ways to reverse the effects of pathological ERK/MAP kinase — with the goal of stimulating neurological recovery.

Education

  • Ph.D. Wake Forest University - School of Medicine 2006                        
  • B.S. University of Michigan-Ann Arbor 2000                                     

 

Google Scholar

Research Interests

      My research is focused on the development of the nervous system, specifically the biochemical and cellular mechanisms that direct the formation of the brain and spinal cord. Work in the laboratory employs a wide range of genetic, cellular, and molecular techniques to investigate the development of neurons and glia in distinct regions of the spinal cord and cerebral cortex.  We are particularly interested in a related group of human neurodevelopmental syndromes that are caused by abnormalities in a protein known as ERK/MAP kinase. Neurofibromatosis Type 1, Noonan-, and CFC-Syndrome are the most common syndromes in this group. Recent work suggests ERK/MAP kinase may even be involved in certain autism spectrum disorders and schizophrenia.  We are currently focused on defining precisely how ERK/MAP kinase dysfunction leads to defects in nervous system development.  The laboratory utilizes a combination of genetically-modified mice, high-resolution microscopy, viral vector tracing, cell-based assays, pharmacological manipulations, next-generation sequencing, and behavioral assessments to explore kinase functions in the brain.  We are also exploring strategies to reverse pathological ERK/MAP kinase activity with the goal of promoting neurological recovery.

Research Group

George Reed Bjorklund - Molecular and Cellular Biology PhD Student

Michael Holter - Interdisciplinary Program in Neuroscience PhD Student

Rebecca Sebastian - Accelerated Masters Program in Biology

Kenji Nishimura - Research Technician

Shiv Shah - Undergraduate Researcher (SOLUR)

Chris Wedwick - Undergraduate Researcher (SOLUR)

Katie Riordan - Undergraduate Researcher

Danielle Gonzalez - Undergraduate Researcher

Publications

Tokuyama M*, Xu C*, Fisher R, Wilson-Rawls J, Kusumi K, Newbern JM (2017) Developmental and adult-specific processes contribute to de novo neuromuscular regeneration in the lizard tail. Developmental Biology

Sinakevitch IT, Bjorklund GR, Newbern JM, Gerkin RC, and Smith BH. (2017) Comparative study of chemical neuroanatomy of the olfactory neuropil in mouse, honey bee and human. Biological Cybernetics. Epub ahead of print. PMID: 28852854

Blazie SM, Wilky H, Joshi R, Newbern JM, Mangone M. (2017) Alternative polyadenylation coordinates tissue specific miRNA targeting in Caenorhabditis elegans somatic tissues. Genetics 206(2):757-774. PMID: 28348061

Lewis CR, Manning TB, Himes SM, Bastle R, Fennig P, Conrad PR, Colwell J, Pagni BA, Hess LA, Matekel CG, Newbern JM, Olive MF. (2016) Interactions between Early Life Stress, Nucleus Accumbens MeCP2 Expression, and Methamphetamine Self-Administration in Male Rats. Neuropsychopharmacology  PMCID: PMC5061895

Xing L, Larsen R, Bjorklund GR, Li X , Wu Y, Philpot BD, Snider WD, Newbern JM. (2016) Layer-specific and general requirements for ERK/MAPK signaling in the developing neocortex. Elife  Feb 5;5 pii: e11123. PMCID: PMC4758957

Yi J, Berrios J, Newbern JM, Snider WD, Philpot BD, Hahn KM, Zylka MJ (2015) An Autism-Linked Mutation Disables Phosphorylation Control of UBE3A. Cell 162(4):795-807 PMCID: PMC4537845

Newbern JM. (2015) Molecular control of the neural crest and peripheral nervous system development. Curr Topics in Developmental Biology 111:201-31 PMCID: PMC4517674

Maynard TM, Gopalakrishna D, Meechan D, Paronett E, Newbern JM, LaMantia AS. (2013)  22q11 gene dosage establishes an adaptive range for sonic hedgehog and retinoic acid signaling during early development. Human Molecular Genetics. 22(2):300-12. PMCID: PMC3526161

Xing L, Newbern JM, Snider WD. (2013) Neuronal Development: SAD Kinases make happy axons. Curr Biol  “Dispatch” 23(17):R720-3. PMCID: PMC3947747

Li X, Newbern JM, Wu Y, Morgan-Smith M, Zhong J, Charron J, Snider WD. (2012) MEK is a key regulator of gliogenesis in the developing brain. Neuron. 75(6):1035-50. PMCID: PMC3483643

Newbern JM, Snider WD. (2012) Bers-ERK Schwann Cells Coordinate Nerve Regeneration. Neuron. “Preview” 73(4):623-626.

Newbern JM, Li X, Shoemaker S, Zhong J, Zhou J, Wu Y, Bonder D, Hollenback S, Coppola G, Geschwind D, Landreth GE, Snider WD. (2011) Specific functions for ERK/MAPK signaling during PNS development. Neuron. 69(1):1-15. PMCID: PMC3060558

Newbern JM, Birchmeier C. (2010) Nrg1/ErbB signaling networks in Schwann cell development and myelination.  Seminars in Cell and Developmental Biology. 21(9):922-928. PMCID: PMC2991617

Newbern JM, Shoemaker S, Snider WD. (2009) Taking off the SOCS: cytokine signaling spurs regeneration. Neuron. “Preview” 64(5):591-2.

Newbern JM, Zhong J, Wickramasinghe RS, Li X, Wu Y, Samuels I, Cherosky N, Karlo JC, O'Loughlin B, Wikenheiser J, Gargesha M, Doughman YQ, Charron J, Ginty DD, Watanabe M, Saitta SC, Snider WD, Landreth GE. (2008) Mouse and human phenotypes indicate a critical conserved role for ERK2 signaling in neural crest development. Proc Natl Acad Sci 105(44):17115-20. PMCID: PMC2579387

Macosko JC, Newbern JM, Rockford J, Chisena E, Brown C, Holzwarth GM, and Milligan CE. (2008) Fewer active motors per vesicle may explain slowed vesicle transport in chick motoneurons after three days in vitro.  Brain Research 1211:6-12. PMCID: PMC2464625

Taylor AR, Gifondorwa DJ, Newbern JM, Robinson MB, Strupe JL, Prevette D, Oppenheim RW, and Milligan CE.  (2007) Astrocyte and Muscle-derived Secreted Factors Differentially Regulate Motoneuron Survival. J. Neuroscience 27(3):634-644

Newbern J, Taylor AR, Robinson MB, Lively MO, Milligan CE.  (2007) JNK signaling regulates events associated with both health and degeneration in motoneurons.  Neuroscience 47(3):680-692

Robinson MB, Tidwell JL, Gould T, Taylor AR, Newbern JM, Graves J, Tytell M, Milligan CE.  (2005) Extracellular Heat Shock Protein 70: A Critical Component for Motoneuron Survival. J. Neuroscience 25(42):9735-45

Newbern JM, Taylor AR, Robinson MB, Li L, Milligan CE.  (2005) Decreases in PI3K and ERK1/2 signaling activate components of spinal motoneuron death.  J. Neurochemistry 94:1652-1665

Sun W, Gould T, Newbern JM, Milligan CE, Choi SY, Kim H, Oppenheim RW. (2005) Phosphorylation of c-Jun in Avian and Mammalian Motoneurons In Vivo during Programmed Cell Death: An Early Reversible Event in the Apoptotic Cascade.  J. Neuroscience 25(23):5595-5603.

Research Activity

NIH-HHS (NINDS) - R01 NS097537                            Role: PI                                                \

Functions of ERK/MAPK Signaling in GABAergic Circuit Development

 

NIH-HHS (NIAAA) - R01 MH110433                            Role: Co-I (PI: Olive, Psychology)             

Brain endorphin targets of low dose alcohol

 

AZ Biomedical Res. Comm. ADHS #00003606         Role: Co-PI (PI: Baumbach-Reardon, UA-Phoenix)     

Identification and functional characterization of novel neuromuscular disease-causing variants in

Arizona infants and children

Courses

Fall 2018
Course Number Course Title
BIO 351 Developmental Biology
BIO 492 Honors Directed Study
BIO 493 Honors Thesis
MBB 495 Undergraduate Research
BIO 495 Undergraduate Research
MCB 501 Seminar:Molecular/Cell Biology
NEU 591 Seminar
MCB 701 Seminar:Molecular/Cellular Bio
Spring 2018
Course Number Course Title
BIO 492 Honors Directed Study
BIO 493 Honors Thesis
BIO 494 Special Topics
BIO 495 Undergraduate Research
MCB 501 Seminar:Molecular/Cell Biology
NEU 591 Seminar
BIO 598 Special Topics
MCB 701 Seminar:Molecular/Cellular Bio
Fall 2017
Course Number Course Title
BIO 351 Developmental Biology
BIO 492 Honors Directed Study
MBB 495 Undergraduate Research
BIO 495 Undergraduate Research
MCB 501 Seminar:Molecular/Cell Biology
NEU 591 Seminar
MCB 591 Seminar
MCB 701 Seminar:Molecular/Cellular Bio
Spring 2017
Course Number Course Title
BIO 467 Neurobiology
BIO 493 Honors Thesis
BIO 495 Undergraduate Research
MCB 501 Seminar:Molecular/Cell Biology
MCB 701 Seminar:Molecular/Cellular Bio
Fall 2016
Course Number Course Title
BIO 351 Developmental Biology
BIO 492 Honors Directed Study
MBB 495 Undergraduate Research
BIO 495 Undergraduate Research
MCB 501 Seminar:Molecular/Cell Biology
NEU 591 Seminar
MCB 591 Seminar
MCB 701 Seminar:Molecular/Cellular Bio
Spring 2016
Course Number Course Title
BIO 467 Neurobiology
BIO 492 Honors Directed Study
BIO 493 Honors Thesis
BIO 495 Undergraduate Research
MCB 701 Seminar:Molecular/Cellular Bio
Fall 2015
Course Number Course Title
BIO 189 Life Sciences Career Paths
BIO 492 Honors Directed Study
BIO 494 Special Topics
MBB 495 Undergraduate Research
BIO 495 Undergraduate Research
MCB 501 Seminar:Molecular/Cell Biology
MCB 591 Seminar
BIO 598 Special Topics
MCB 701 Seminar:Molecular/Cellular Bio
Spring 2015
Course Number Course Title
BIO 467 Neurobiology
BIO 493 Honors Thesis
BIO 495 Undergraduate Research
Fall 2014
Course Number Course Title
BIO 189 Life Sciences Career Paths
BIO 492 Honors Directed Study
MBB 495 Undergraduate Research
BIO 495 Undergraduate Research
Spring 2014
Course Number Course Title
BIO 467 Neurobiology
MBB 495 Undergraduate Research
BIO 495 Undergraduate Research

Honors/Awards

NIH PECASE Nominee                                                                                                              2016

NIH Pathway to Independence Award                                                                               2011-2016

NIH National Research Service Award                                                                              2009-2011

UNC Developmental Biology Training Program Postdoctoral Fellowship                           2007-2008

Western North Carolina Society for Neuroscience  Poster Winner                                           2003

Professional Associations

American Society for Neurochemistry                                                                           2015-present

Arizona Imaging and Microanalysis Society                                                                  2014-present

Society for Neuroscience (USA)                                                                                   2002-present

Western North Carolina Society for Neuroscience                                                        2001 - 2006

Service

International Society for Neuroscience Conference: Session Co-Chair

Minisymposium: 191 - Building the Cerebral Cortex                                                                      2016

American Heart Association - Basic Cell Genetics and Epigenetics-2 Committee                        2016

National Science Foundation Grant Reviewer                                                                               2008

 

Arizona State University

Breakout Session Organizer: ASU-Neuroscience Conference                                                      2017

Member: Animal Users Advisory Committee                                                                   2015-present

Member: Clinical Veterinarian Search Committee                                                                         2015

DACT In-Service Seminar “Genetic approaches to study the developing mouse”                6/14/2015

Member: Undergraduate Programs Committee                                                                2017-present

Director: Neuroscience Research Seminar                                                                       2017-present

Panel Participant: SoLS Graduate Student Retreat                                                                3/26/2017

Member: Stem Cell Biology Faculty Search Committee                                                        2016-2017

Poster Judge: MCB Retreat                                                                               10/14/2015, 10/10/2017

Co-Director: MCB Colloquium (MCB 501/701)                                                                  2015-present

Interim Member: SoLS Director Search Committee                                                               2014-2015

Member: School of Life Sciences/School of Art Collaborative Committee                                      2014