Jeffrey Kleim

Associate Professor
Faculty
TEMPE Campus
Mailcode
9709
Assoc Professor
Faculty
TEMPE Campus
Mailcode
9709
Associate Professor (School of Biological and Health Systems Engineering)
Faculty
TEMPE Campus
Mailcode
9709

Biography

Jeffrey Kleim is an associate professor and associate director of the School of Biological and Health Systems Engineering at Arizona State University. He studies how neural plasticity supports learning in the intact brain and “relearning” in the damaged or diseased brain. His research is directed at developing therapies that optimize plasticity in order to enhance recovery after stroke and Parkinson’s Disease. The brain is a highly dynamic organ that is capable of structural and functional reorganization in response to a variety of manipulations. This neural plasticity is the mechanism by which the brain encodes experience. His laboratory examines how plasticity within rat and human motor cortex supports learning in the intact brain and “relearning” after stroke. His group uses intracortical microstimulation in rats and transcranial magnetic stimulation in humans to examine how motor training alters the functional organization of motor cortex. This work has demonstrated that rehabilitation-dependent recovery of motor function after stroke is associated with a reorganization of movement representations in rodent motor cortex. Furthermore, there are specific behavioral and neural signals that drive both recovery and plasticity. These experiments are being used to test novel therapies for enhancing motor recovery in stroke patients.

Education

Ph.D. Psychology, University of Illinois 1997

 

Research Interests

Jeffrey Kleim studies how neural plasticity supports learning in the intact brain and relearning in the damaged or diseased brain. His research is directed at developing therapies that optimize plasticity in order to enhance recovery after stroke and Parkinsons Disease. The brain is a highly dynamic organ that is capable of structural and functional reorganization in response to a variety of manipulations. This neural plasticity is the mechanism by which the brain encodes experience. His laboratory examines how plasticity within rat and human motor cortex supports learning in the intact brain and relearning after stroke. Kleim's group uses intracortical microstimulation in rats and transcranial magnetic stimulation in humans to examine how motor training alters the functional organization of motor cortex. This work has demonstrated that rehabilitation-dependent recovery of motor function after stroke is associated with a reorganization of movement representations in rodent motor cortex. Furthermore, there are specific behavioral and neural signals that drive both recovery and plasticity. These experiments are being used to test novel therapies for enhancing motor recovery in stroke patients.

Research Activity

Courses

Spring 2022
Course Number Course Title
BME 100 Intro to Biomed Engineering
BME 494 Special Topics
NEU 556 Human Systems Neuroscience
BME 556 Human Systems Neuroscience
NEU 598 Special Topics
BME 598 Special Topics
Fall 2021
Course Number Course Title
BME 100 Intro to Biomed Engineering
ASU 101-BME The ASU Experience
Spring 2021
Course Number Course Title
BME 100 Intro to Biomed Engineering
BME 494 Special Topics
NEU 598 Special Topics
BME 598 Special Topics
Fall 2020
Course Number Course Title
BME 100 Intro to Biomed Engineering
BME 394 Special Topics
BME 492 Honors Directed Study
BME 493 Honors Thesis
BME 592 Research
BME 599 Thesis
BME 792 Research
Summer 2020
Course Number Course Title
BME 494 Special Topics
NEU 598 Special Topics
BME 598 Special Topics
Spring 2020
Course Number Course Title
BME 100 Intro to Biomed Engineering
BME 394 Special Topics
BME 492 Honors Directed Study
BME 493 Honors Thesis
BME 494 Special Topics
BME 592 Research
BME 598 Special Topics
NEU 598 Special Topics
BME 599 Thesis
BME 792 Research
Fall 2019
Course Number Course Title
BME 100 Intro to Biomed Engineering
BME 394 Special Topics
BME 492 Honors Directed Study
BME 493 Honors Thesis
BME 592 Research
BME 599 Thesis
BME 792 Research
Summer 2019
Course Number Course Title
BIO 495 Undergraduate Research
Spring 2019
Course Number Course Title
BME 100 Intro to Biomed Engineering
BME 394 Special Topics
BME 492 Honors Directed Study
BME 493 Honors Thesis
BME 494 Special Topics
BME 592 Research
BME 598 Special Topics
NEU 598 Special Topics
BME 599 Thesis
BME 792 Research
Fall 2018
Course Number Course Title
BME 100 Intro to Biomed Engineering
BME 394 Special Topics
BME 492 Honors Directed Study
BME 493 Honors Thesis
BME 592 Research
BME 599 Thesis
BME 792 Research
Summer 2018
Course Number Course Title
BME 394 Special Topics
BIO 495 Undergraduate Research
Spring 2018
Course Number Course Title
BME 100 Intro to Biomed Engineering
BME 394 Special Topics
BME 492 Honors Directed Study
BME 493 Honors Thesis
BME 494 Special Topics
BME 592 Research
BME 598 Special Topics
NEU 598 Special Topics
BME 599 Thesis
BME 792 Research
Fall 2017
Course Number Course Title
BME 100 Intro to Biomed Engineering
BME 394 Special Topics
BME 484 Internship
BME 492 Honors Directed Study
BME 493 Honors Thesis
Summer 2017
Course Number Course Title
BME 394 Special Topics
BIO 495 Undergraduate Research