M. Foster Olive
Biography
M. Foster Olive heads the Addiction Neuroscience Laboratory at Arizona State University. His group is interested in examining how abused drugs affect the brain on a neurobiological level.
He received his undergraduate degree in psychology from University of California at San Diego, and his doctoral degree in neuroscience from University of California at Los Angeles. His postdoctoral research was performed at Stanford University and the University of California at San Francisco. His research has been published in journals such as Psychopharmacology, Biological Psychiatry, Journal of Neuroscience, and Nature Neuroscience, and he currently serves on the editorial boards for Neuropsychopharmacology, Addiction Biology, Neuropharmacology, and Frontiers in Pharmacology. Professor Olive’s research is supported by the National Institute on Alcohol Abuse and Alcoholism and the National Institute on Drug Abuse.
Education
- Postdoctoral Research Fellow and Senior Scientist, University of California-San Francisco, 1998-2003
- Postdoctoral Research Fellow, Stanford University, 1997-1998
- Ph.D. Neuroscience, University of California-Los Angeles 1997
- B.A. Psychology, University of California-San Diego 1991
Research Interests
His group is interested in examining how abused drugs affect the brain on a neurobiological level. Specifically, what long-lasting changes do abused drugs produce in the brain that ultimately result in dependence and addiction? Can these changes be minimized or reversed? What makes some individuals vulnerable to addiction while others are resilient? Under what circumstances, and in what brain regions, do drugs produce toxic effects on neurons and other cell types? Given the poor outcomes of existing treatments for addictive disorders, our ultimate goal is to identify novel biological targets for innovative therapies that can be integrated into other treatment approaches to facilitate healing of the addicted brain.
Current research projects in the laboratory utilize model organisms to examine:
- The neural circuits and neurochemical mechanisms underlying the ability of alcohol to active brain endorphin systems
- The abuse liability and neurotoxicity of emerging drugs of abuse such as synthetic cathinones ( bath salts )
- Interactions between social and neurobiological factors that underlie addiction to heroin and other opiates
- The ability of abused drugs to induce lasting morphological (structural) changes in neurons
- Mechanisms of alcohol dependence and co-abuse with psychostimulants
- Optogenetic and chemogenetic control of neural circuits that underlie addictive behaviors
Research Group
Addiction Neuroscience Laboratory
https://psychology.clas.asu.edu/research/labs/addiction-neuroscience-laboratory-olive
Publications
- Lewis CR, Olive MF. Early life stress interactions with the epigenome: potential mechanisms driving vulnerability towards psychiatric illness. Behavioural Pharmacology 25:341-351, 2014.
- Watterson LR, Kufahl PR, Nemirovsky NE, Sewalia K, Grabenauer M, Thomas BF, Marusich JA, Wegner S, Olive MF. Potent rewarding and reinforcing effects of the synthetic cathinone 3,4-methylenedioxypyrovalerone. Addiction Biology 19:165-175, 2014.
- Olive MF (ed). Metabotropic Glutamate Receptors: Molecular Mechanisms, Role in Neurological Disorders, and Pharmacological Effects. Nova Science Publishers: Hauppauge NY, 2014.
- LaCrosse AL, Taylor SB, Nemirovsky NE, Gass JT, Olive MF. mGluR5 positive and negative allosteric modulators differentially affect dendritic spine density and morphology in the prefrontal cortex. CNS & Neurological Disorders – Drug Targets 14:476-485, 2015.
- Burrows BT, Watterson LR, Johnson MA, Olive MF. Effects of modafinil and R-modafinil on brain stimulation reward thresholds: implications for their use in the treatment of psychostimulant dependence. Journal of Drug and Alcohol Research 4, Article ID 235958, 2015.
- Taylor SB, Conrad CD, Olive MF. Stress and spatial maze performance in the rat. In: The Maze Book: Theories, Practice, and Protocols for Testing Rodent Cognition (Bimonte-Nelson HA, ed), Springer Protocols/Humana Press, pp. 211-258, 2015.
- Taylor SB, Watterson LR, Kufahl PR, Nemirovsky NE, Tomek SE, Conrad CD, Olive MF. Chronic variable stress and intravenous methamphetamine self-administration – role of individual differences in behavioral and physiological reactivity to novelty. Neuropharmacology 108:353-363, 2016.
- Olive MF. Glutamate receptors and drug addiction. In: The Neuropathology of Drug Addictions and Substance Misuse – Volume 3 (Preedy VR, ed), Elsevier Publishers, New York, 2016, pp. 102-110.
Research Activity
- Olive,Michael Foster*. Mechanisms of regualtion of ethanol intakeby lateral habenula. RUTGERS UNIV(4/1/2014 - 3/31/2015).
- Olive,Michael Foster*. Optogenetic Targeting of mGluR5 Receptor Signaling in Addiction. HHS-NIH-NIDA(3/1/2014 - 2/29/2016).
- Olive,Michael Foster*. Chromatin Alterations Produced by Drugs of Abuse and Binge Eating. ASU-Mayo Seed Grant(1/1/2014 - 12/31/2014).
- Olive,Michael Foster*. Novel Treatments for HIV Encephalitis in Mice. VAMC(4/30/2011 - 9/30/2011).
- Olive,Michael Foster*. To examine the effects of novel ALDH2 inhibitors on cue-induced reinstatement of cocaine-seeking behavior. Gilead(2/10/2011 - 11/15/2011).
- Olive,Michael Foster*. Control of Ethahnol Intake by an mGluR5-PKCe Pathway. HHS-NIH-NIAAA(11/1/2010 - 4/30/2015).
- Olive,Michael Foster*. mGluR5 antagonists for methamphetamine addiction. HHS-NIH-NIDA(7/1/2010 - 6/30/2014).
- Olive,Michael Foster*. Metabotropic Glutamate Receptor Signaling and Extinction Learning. HHS-NIH-NIDA(7/1/2010 - 12/31/2013).
Courses
| Spring 2021 | |
|---|---|
| Course Number | Course Title |
| PSY 399 | Supervised Research |
| PSY 499 | Individualized Instruction |
| PSY 591 | Seminar |
| Fall 2020 | |
|---|---|
| Course Number | Course Title |
| PSY 307 | Your Brain on Drugs |
| PSY 399 | Supervised Research |
| BIO 495 | Undergraduate Research |
| PSY 499 | Individualized Instruction |
| PSY 591 | Seminar |
| Spring 2020 | |
|---|---|
| Course Number | Course Title |
| PSY 399 | Supervised Research |
| PSY 499 | Individualized Instruction |
| PSY 799 | Dissertation |
| Fall 2019 | |
|---|---|
| Course Number | Course Title |
| PSY 307 | Your Brain on Drugs |
| PSY 399 | Supervised Research |
| BIO 495 | Undergraduate Research |
| PSY 499 | Individualized Instruction |
| PSY 799 | Dissertation |
| Spring 2019 | |
|---|---|
| Course Number | Course Title |
| PSY 399 | Supervised Research |
| PSY 499 | Individualized Instruction |
| Fall 2018 | |
|---|---|
| Course Number | Course Title |
| PSY 307 | Your Brain on Drugs |
| PSY 399 | Supervised Research |
| BIO 495 | Undergraduate Research |
| PSY 499 | Individualized Instruction |
| Summer 2018 | |
|---|---|
| Course Number | Course Title |
| BIO 495 | Undergraduate Research |
| Spring 2018 | |
|---|---|
| Course Number | Course Title |
| PSY 399 | Supervised Research |
| BIO 495 | Undergraduate Research |
| PSY 499 | Individualized Instruction |
| PSY 591 | Seminar |
| Fall 2017 | |
|---|---|
| Course Number | Course Title |
| PSY 399 | Supervised Research |
| PSY 470 | Psychopharmacology |
| BIO 495 | Undergraduate Research |
| PSY 499 | Individualized Instruction |
| PSY 570 | Psychopharmacology |
| Summer 2017 | |
|---|---|
| Course Number | Course Title |
| BIO 495 | Undergraduate Research |
| Spring 2017 | |
|---|---|
| Course Number | Course Title |
| PSY 399 | Supervised Research |
| PSY 426 | Neuroanatomy |
| BIO 495 | Undergraduate Research |
| PSY 499 | Individualized Instruction |
| PSY 526 | Neuroanatomy |
| Fall 2016 | |
|---|---|
| Course Number | Course Title |
| PSY 399 | Supervised Research |
| BIO 495 | Undergraduate Research |
| PSY 499 | Individualized Instruction |
| Summer 2016 | |
|---|---|
| Course Number | Course Title |
| BIO 495 | Undergraduate Research |
Presentations
2014
Invited Speaker, Synthetic cathinones ( bath salts ): recent studies on assessment of their abuse liability and toxicity , California State University at Long Beach and California State University at San Bernardino, CA
Invited Speaker, NK1 antagonists for stimulant use disorders , Emerging Targets for Stimulant Use Disorders Meeting, National Institute on Drug Abuse, Bethesda, MD
Invited Speaker, Development of a viral construct expressing a light-activated mGluR5 receptor (OptoXR-mGluR5) for optogenetic applications , 8th International Meeting on Metabotropic Glutamate Receptors, Taormina, Sicily, Italy
Invited Panelist, Town Hall Debate, Lessons from Colorado: Legalizing marijuana is good for Arizona communities , School of Social and Behavioral Sciences, Arizona State University West Campus
2015
Invited Panelist, Early life stress effects on methamphetamine self-administration: a potential role for MeCP2 , Winter Conference on Brain Research, Big Sky, MT
Invited Speaker, Progress towards development of a viral construct expressing a light-activated mGluR5 receptor (OptoXR-mGluR5) for optogenetic applications , Biosciences Division, SRI International, Menlo Park, CA
Invited Speaker, Effects of mGluR5 receptor potentiation in rodent models of addiction: pharmacological studies and new optogenetic tools , Department of Neuroscience, University of Minnesota, Minneapolis, MN
Invited Panelist, Glutamatergic medications for substance use disorders are we there yet? Annual Meeting of the International Behavioral Neuroscience Society, Victoria, British Columbia, Canada
2016
Invited Panelist, Repeated binge-like intake of the synthetic cathinone MDPV and its cognitive and neurological sequelae , Winter Conference on Brain Research, Breckenridge, CO
Invited Speaker, Potential neurotoxic and neuroinflammatory effects of long-term intake of the synthetic cathinone MDPV , Department of Pharmacology, Center for Substance Abuse Research, Lewis Katz School of Medicine at Temple University, Philadelphia, PA
Honors/Awards
2006 Elected to American College of Neuropsychopharmacology as Associate Member
2007 Nominee, Pew Scholars Program in Biomedical Sciences, Medical University of South Carolina
2011 Elected to American College of Neuropsychopharmacology as Regular Member
2012 Nominee, Zebulon Pearce Distinguished Teaching Award, College of Liberal Arts and Sciences, Arizona State University
2015 Elected to Leadership Academy, Neuroscience Team, Office of Knowledge and Enterprise Development, Arizona State University
Editorships
Editorial Board Memberships
CNS & Neurological Disorders Drug Targets
Addiction Biology
Neuropsychopharmacology
Behavioural Pharmacology
Journal of Drug and Alcohol Research
Recent Patents on CNS Drug Discovery
Frontiers in Pharmacology
Neuropharmacology
Guest Editor
Neuronal and glial structural plasticity induced by drugs of abuse , Special Research Topic of Frontiers in Pharmacology
Professional Associations
Society for Neuroscience, International Society for Neurochemistry, Research Society on Alcoholism, International Drug Abuse Research Society, American College of Neuropsychopharmacology, American Society for Pharmacology and Experimental Therapeutics, College on Problems of Drug Dependence, Society for the Study of Addiction
Service
Student Affairs and Grievances Committee, College of Liberal Arts and Sciences, Arizona State University
Leadership Academy, Neuroscience Team, Arizona State University
University Laboratory Safety Committee, Arizona State University
Board of Scientific Counselors, Intramural Research Program, National Institute on Drug Abuse
Neuroscience Review Subcommittee AA-4, National Institute on Alcohol Abuse and Alcoholism
Special Award Judge, National Institute on Drug Abuse, Intel International Science and Engineering Fair (ISEF), Society for Science & the Public
Membership Committee, College on Problems of Drug Dependence and American College of Neuropsychopharmacology
Education and Training Committee, American College of Neuropsychopharmacology
Ad hoc reviewer for Israel Science Foundation, Foundation for Polish Science, Czech Science Foundation, National Science Foundation, Neurological Foundation of New Zealand, United States Army Medical Research and Materiel Command Broad Agency Announcement for Extramural Medical Research
Graduate Faculties / Mentoring History
Doctoral Dissertation Committees (chair or co-chair): Amber LaCrosse (Department of Psychology, 2010-2014), Lucas Watterson (Department of Psychology, 2011-2014), Candace Lewis (Department of Psychology, 2011-2015), Elizabeth Watterson (Department of Psychology, 2011-2015), Devin Taylor (Interdisciplinary Graduate Program in Neuroscience, 2011-2015), Seven Tomek (Department of Psychology, 2016-present)
Work History
2003-2005 Adjunct Assistant Professor, Department of Neurology, University of California at San Francisco; 2005-2010 Assistant Professor, Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina; 2010-2012 Assistant Professor, Department of Psychology, Arizona State University; 2012-present, Associate Professor with Tenure, Department of Psychology, Arizona State University
Novel coronavirus information
Spring 2021 update | FAQ page | Class flexibility for students | Novel coronavirus updates