Madhavi Chakravadhanula

Project Coordinator
Faculty
TEMPE Campus
Mailcode
4501

Biography

Madhavi Chakravadhanula manages the Initiative for Maximizing Student Development (IMSD), an NIH funded STEM initiative to encourage underrepresented students to achieve their career goals in science. A Scientist with seventeen years of laboratory research experience and peer-reviewed publications, Madhavi works with IMSD undergraduates and graduates to help them effectively reach their scientific aspirations. Besides interacting with the IMSD students, her experience as a Biology Instructor has enhanced her interactions with ASU undergraduates interested in Biology. She has taught BIO 181, BIO 100, co-taught SOLUR / IMSD seminar, and IMSD seminar classes, thus has always been in touch with various undergraduate and graduate research projects. Madhavi is also currently involved in a research project in the Newfeld lab. Her research interests include, intracellular signaling, cell cycle regulation, and cancer biology. 

Education

Ph.D., Cell and Molecular Biosciences, Arizona State University Tempe, AZ. 

M.S., Cell and Molecular Biology, West Virginia University,

Morgantown, WV. 

M.Sc., Life Sciences, University of Madras, India. 

B.Sc., Zoology, University of Madras, India

Research Interests

Intra cellular signal transduction

Cell cycle regulation

Cancer biology especially human brain cancer

Research Group

Center for Biology and Society, Human Dimensions group

Publications

1. Wnt pathway in atypical teratoid rhabdoid tumors. Chakravadhanula M, Hampton CN, Chodavadia P, Ozols V, Zhou L, Catchpoole D, Xu J, Erdreich-Epstein A, Bhardwaj RD. Neuro Oncol. 2014 Sep 21. pii: nou229. [Epub ahead of print]

2. Expression of the HOX genes and HOTAIR in atypical teratoid rhabdoid tumors and other pediatric brain tumors. Chakravadhanula M, Ozols VV, Hampton CN, Zhou L, Catchpoole D, Bhardwaj RD. Cancer Genet. 2014 Jun 10 [Epub].

3. Detection of an ATRT Brain Tumor Gene Deletion Diagnostic in Circulating Blood using Next Gen Sequencing. Chakravadhanula M, Tembe W, Legendre C, Carpentieri D, Liang WS, Bussey KJ, Carpten J, Berens ME, Bhardwaj RD. J. Child Neurology, EPUB 2013.

4. Involvement of MEK, ERK, PKCζ and GSK3β in Maintaining the Mitotic Spindle. Kalive M and Capco DG. International Journal of Biology. 2013. 5(2):1-18.

5. Human intestinal epithelial cells exhibit a cellular response indicating a potential toxicity upon exposure to hematite nanoparticles.  Kalive M, Zhang W, Chen Y, Capco DG. Cell Biol. Toxicol. 2012. 28(5):343-68. Epub 2012 Aug 19.

6. Involvement of PKCζ and GSK3β in the stability of the metaphase spindle. Kalive M, Baluch DP, Capco DG.  In Vitro Cell Dev Biol Anim. 2011 Dec 17. [Epub]

7. Adsorption of hematite nanoparticles onto Caco-2 cells and the cellular impairments: effect of particle size.  Zhang W, Kalive M, Capco DG, Chen Y.  Nanotechnology. 2010 Sep 3;21(35):355103.

8. Involvement of the PKC family in regulation of early development.  Kalive M, Faust JJ,          Koeneman BA, Capco DG.  Mol Reprod Dev. 2010 Feb;77(2):95-104. Review.

9. Drosophila doubletime mutations which either shorten or lengthen the period of circadian            rhythms decrease the protein kinase activity of casein kinase I.  Preuss F, Fan JY, Kalive M, Bao S, Schuenemann E, Bjes ES, Price JL.  Mol Cell Biol. 2004 Jan;24(2):886-98.

10. A gene located at 72A in Drosophila melanogaster encodes a novel zinc-finger protein that interacts with protein kinase CK2.  Kalive M, Trott RL, Bidwai AP.  Mol Cell Biochem. 2001 Nov;227(1-2):99-105.

11. Identification and characterization of proteins that interact with Drosophila melanogaster protein kinase CK2.  Trott RL, Kalive M, Karandikar U, Rummer R, Bishop CP, Bidwai AP.  Mol Cell Biochem. 2001 Nov;227(1-2):91-8.

12. Drosophila melanogaster casein kinase II interacts with and phosphorylates the basic helix-loop-helix proteins m5, m7, and m8 derived from the Enhancer of split complex.  Trott RL, Kalive M, Paroush Z, Bidwai AP.  J Biol Chem. 2001 Jan 19;276(3):2159-67.

BOOK CHAPTERS

  1. PKC Regulation of Gametogenesis and Early Development, Meiosis - Molecular Mechanisms and Cytogenetic Diversity.  Faust J, Kalive M, Anup Abraham, Capco DG Andrew Swan (Ed.), ISBN: 978-953-51-0118-5, InTech. 2012. Available from: http://www.intechopen.com/articles/show/title/pkc-regulation-of-gametogenesis-and-early-development.

Research Activity

Cellular signal transduction pathway in the model organism, Drosophila melanogaster

Courses

Spring 2018
Course Number Course Title
BIO 112 Discovery - Why Sex?
BIO 181 General Biology I
BIO 494 Special Topics
Fall 2017
Course Number Course Title
BIO 112 Discovery - Why Sex?
BIO 189 Life Sciences Career Paths
BIO 494 Special Topics
Spring 2017
Course Number Course Title
BIO 289 SOLUR Apprentice
BIO 389 SOLUR Researcher
BIO 489 SOLUR Fellow
BIO 494 Special Topics
Fall 2016
Course Number Course Title
BIO 100 The Living World
BIO 494 Special Topics
Spring 2016
Course Number Course Title
BIO 181 General Biology I
Fall 2015
Course Number Course Title
BIO 181 General Biology I
Spring 2015
Course Number Course Title
BIO 181 General Biology I