Causes and consequences of human genetic variation

Life Sciences Café with Sohini Ramachandran

Determining the genomic elements underlying adaptive evolution and diseases in a species is essential for connecting genetic variation to phenotypes and fitness, but current statistical methods overlook the confounding effect population histories have on the identification and localization of adaptive and disease-associated mutations. I'll discuss two methods developed in my laboratory that (i) model the complex interaction between various modes of selection and population histories; and (ii) accurately identify and localize mutations, genes, and pathways underlying adaptive traits and disease for further experimental validation. These methods can be extended and applied to existing and emerging genome- wide polymorphism and next-generation sequencing datasets for humans and a range of other organisms. Our goal is to yield new insight into the interaction between selection and dynamic population histories in generating human genetic diversity and the human phenotype.

Sohini Ramachandran

Heather Bean
Monday, Feb. 20 | Noon - 1 p.m.
LSE 244
School of Life Sciences - E wing