Qiang Chen

Professor
Faculty
TEMPE Campus
Mailcode
7501

Biography

Qiang “Shawn” Chen is a molecular biologist who specializes in developing novel human therapeutics and vaccines in plants to combat infectious diseases, cancer, and biological warfare agents. His research aims to ameliorate diseases and improve human health, as well as to contribute new knowledge to the basic understanding of how gene expression and protein modification are regulated in plants.  

Professor Chen and his team use rational design strategies to develop biologics that possess superior efficacy and safety. Flavivirus therapeutics and vaccine development and the modulation of antibody-dependent enhancement (ADE) of viral infections are part of their research focus. His team has developed monoclonal antibody (MAb) variants in plants that have shown promise in improving brain targeting, eliminating ADE, and enhancing efficacy against West Nile, Dengue and Chikungunya virus compared to their parent MAbs. The disease targets also include SARS-CoV-2, Zika virus, Ebola virus and colorectal cancer. 

In addition, Professor Chen has expertise in QA/QC and biochemistry research under FDA’s cGMP regulations, drawn from his more than a decade of experience in the biotechnology and pharmaceutical industry directing research in both plant and mammalian cell culture systems. He is interested in mentoring students and scientists in these areas of translational research for conducting human clinical trials.  He is also a faculty member at the Center for Immunotherapy, Vaccines and Virotherapy in the Biodesign Institute at ASU.

 

Education

Ph.D. University of Arizona

Google Scholar

Publications

Patents and Patent Applications:

  • Qiang Chen, Huafang Lai. Production of a Monoclonal Antibody Therapeutic against West Nile Virus in Plants.
    U.S. Patent 8663950. 
  • Qiang Chen, H. Lai, J. He  MAb Therapeutics against West Nile Virus with Improved CNS Penetration.
     U. S. Patent 9499608
  • Q. Chen, H. Lai, J. Hurtado. Plant-derived antibodies and derivatives that reduce risk of antibody-dependent. enhancement (ADE) of infection. U. S. Patent 10,982,221B2
  • Z. Huang, Q. Chen, C. Arntzen, H. Mason. A DNA Replication System for High-level Rapid Production of Vaccines and Monoclonal Antibody Therapeutics in Plants. United States Patent 8513397
  • Q. Chen, M. Yang, H. Lai, H. Sun. Vaccines against Zika virus based on Zika structure proteins.  US Patent  15/989,060
  • Q. Chen, M. Yang, H. Lai. Reducing the toxicity of Agrobacterium endotoxin. International Patent PCT/US2018/035422
  • Q. Chen, J. Hurtardo, H. Lai, H. Sun. Plant-produced mabs against chikungunya virus with enhanced effector function and efficacy. US Patent application #62/857,081
  • Q. Chen, M. Yang, H. Sun, H. Lai. Plant produced anti-EGFR mAbs with specific glycosylation to improve the efficacy against cancer. US Patent Appliation #63/188,360
  • Q. Chen, M. Felder. Monoclonal antibody for SARS-CoV-2 Spike protein. US Patent application #63/116,561
  • Q. Chen, C. Jugler, H. Sun, A. Esqueda, M. Felder. COVID-19 Inflammatory Cytokine Storm Treatment. PCT International Application # PCT/US21/26386
  • Q. Chen, C. Jugler, H. Sun, A. Esqueda, M. Felder. Humanized Antibody for SARS-CoV-2 Spike Protein Infusion.  PCT International Application #63/173,763
  • Q. Chen, C. Jugler, H. Sun, A. Esqueda, M. Felder. Treating and Curing COVID-19 Infetion Utilizing a Laser.  PCT International Application # PCT/US21/28368
  • Q. Chen, C. Jugler, H. Sun, A. Esqueda, M. Felder. Antibody Assay for SARS-CoV-2.  US patent application # 63/178,354
  • Q. Chen, B. Hogue, B.  Jacobs. Produced VLPs and RIC Vaccines.  US Patent Appliation #63/168,135
  • B. Hogue, B.  Jacobs, Q. Chen. Optimal Production of SARS-COV-2 Virus-Like Particles (VLPs) produced in Mammalian Cells.  US Patent Appliation #63/168,148
  • B.  Jacobs, B. Hogue, Q. Chen. Highly Attenuated Replication-Competent Ribombiant Poxviruses as a Vaccine Platform for Expressing S Protein/VLP/IC and Methods of Their Use to Elicit Protective Immune Response.  US Patent Appliation #63/168,140. 
  • Q. Chen, H. Sun, M. Felder. Antibody Conjugated nanoparticle assay and treatment for SARS-CoV-2.  US Patent Appliation #63/190,398 
  • Q. Chen, M. Felder. Extracoprpreal treatment for aging”.  US Patent Appliation #63/193,880

 

Research Activity

  • Chen,Qiang*. Extracorporeal treatment of COVID-19. Halberd (9/15/2020 - 12/15/2022).
  • Chen,Qiang*. COVID-19 diagnostics development. UST (4/10/2020 - 12/31/2021).
  • Chen,Qiang*. Plant-produced monoclonal antibody-therapeutics against cancer. GreenBio (5/10/2019 - 12/31/2022).
  • Chen,Qiang*. Bifunctional antibodies with targeted CNS delivery against West Nile virus. HHS-NIH-NIAID (6/1/2014 - 5/31/2017).
  • Zhang, Peiming* and Chen, Qiang*. Biochemical construction of a tripod antibody to target glycoproteins of Ebola virus for immunotherapy. Multicenter Research BDI (7/1/2015-6/30/2016).
  • Chen, Qiang* and Zhang Peiming*. Trackable molecular Trojan horse as a platform for delivery of monoclonal antibody-based biologics into the brain to treat CNS diseases. Multi-Center Research Initiatives BDI (8/1/2014-7/31/2015).
  • Chen,Qiang*. Bifunctional antibodies with targeted CNS delivery against West Nile virus. HHS-NIH-NIAID (6/1/2012 - 5/31/2014).
  • Chen,Qiang*. Alternative Delivery of Human Milk Proteins to Infants. GATES (BILL & MELINDA) FDN (11/1/2011 - 10/31/2013).
  • Arntzen,Charles, Chen,Qiang, Mason,Hugh S. SBC: Commercialization of Norovirus Vaccine Technology in an Arizona Spin-off Company. SFAz (7/1/2008 - 12/31/2009).
  • Chen,Qiang*. Plant-derived MAb therapeutics for West Nile Virus. HHS-NIH-NIAID (8/1/2007 - 7/31/2012).
  • Chen,Qiang*. Targeted Homologous Recombination in Meiotic Plant Cells. USDA (5/15/2007 - 8/31/2008).
  • Chen,Qiang*. Protein Production in Tobacco from an Amplified Inducible System. DOD 8/1/2006 - 1/31/2007).
  • Arntzen,Charles*, Chen,Qiang, Mason,Hugh S. Plant-Derived Vaccines Against Hepatitis C Cooperative Research Center. HHS-NIH-NIAID(8/1/2005 - 7/31/2012).
  • Arntzen,Charles*, Chen,Qiang, Mason,Hugh S. Development of a Vaccine for Ebola Virus in Plant System. HHS-NIH-NIAID(3/15/2005 - 2/28/2011).
  • Arntzen,Charles*, Chen,Qiang, Leket-Mor,Tsafrir Shlomo, Mason,Hugh S. Plant-Made Microbicides and Mucosal Vaccines for STIs. HHS-NIH-NIAID(9/1/2004 - 8/31/2011).

Courses

Summer 2021
Course Number Course Title
BDE 792 Research
Spring 2021
Course Number Course Title
MBB 493 Honors Thesis
MIC 493 Honors Thesis
BIO 493 Honors Thesis
MIC 495 Undergraduate Research
MBB 495 Undergraduate Research
BIO 495 Undergraduate Research
BDE 792 Research
BDE 799 Dissertation
Fall 2020
Course Number Course Title
BIO 492 Honors Directed Study
MBB 492 Honors Directed Study
MBB 493 Honors Thesis
MIC 495 Undergraduate Research
MBB 495 Undergraduate Research
BIO 495 Undergraduate Research
Summer 2020
Course Number Course Title
BDE 792 Research
Spring 2020
Course Number Course Title
MIC 493 Honors Thesis
BIO 493 Honors Thesis
MBB 493 Honors Thesis
MIC 495 Undergraduate Research
BIO 495 Undergraduate Research
MBB 495 Undergraduate Research
MCB 598 Special Topics
BDE 792 Research
BDE 799 Dissertation
Fall 2019
Course Number Course Title
BIO 353 Cell Biology
MBB 492 Honors Directed Study
BIO 492 Honors Directed Study
MBB 493 Honors Thesis
MIC 495 Undergraduate Research
MBB 495 Undergraduate Research
BIO 495 Undergraduate Research
MCB 598 Special Topics
Spring 2019
Course Number Course Title
MIC 493 Honors Thesis
BIO 493 Honors Thesis
MBB 493 Honors Thesis
MIC 495 Undergraduate Research
BIO 495 Undergraduate Research
MBB 495 Undergraduate Research
MCB 598 Special Topics
BDE 792 Research
BDE 799 Dissertation
Fall 2018
Course Number Course Title
BIO 353 Cell Biology
MBB 492 Honors Directed Study
MBB 493 Honors Thesis
MBB 495 Undergraduate Research
MIC 495 Undergraduate Research
MCB 598 Special Topics
Spring 2018
Course Number Course Title
MBB 493 Honors Thesis
MIC 493 Honors Thesis
BIO 493 Honors Thesis
MIC 495 Undergraduate Research
MBB 495 Undergraduate Research
BIO 495 Undergraduate Research
MBB 499 Individualized Instruction
MCB 598 Special Topics
Fall 2017
Course Number Course Title
BIO 353 Cell Biology
MBB 492 Honors Directed Study
MBB 493 Honors Thesis
MBB 495 Undergraduate Research
MIC 495 Undergraduate Research
MCB 598 Special Topics
Summer 2017
Course Number Course Title
MIC 495 Undergraduate Research
Spring 2017
Course Number Course Title
BIO 493 Honors Thesis
MBB 493 Honors Thesis
MIC 495 Undergraduate Research
MBB 495 Undergraduate Research
BIO 495 Undergraduate Research
MBB 499 Individualized Instruction
MCB 598 Special Topics
Fall 2016
Course Number Course Title
BIO 353 Cell Biology
MBB 492 Honors Directed Study
MBB 493 Honors Thesis
MBB 495 Undergraduate Research
MIC 495 Undergraduate Research
MCB 598 Special Topics

Editorships

  • PLOS ONE, Editorial Board Member 
  • International Journal of Molecular Sciences, Editorial Board Member 
  • Heliyon (Elsevier), Editorial Board member 
  • Scientific Advisory Board, Plant-based Vaccines, Antibodies, and Biologics, Member 
  • Scientific Advisory Board, BioStrategies, Member 
  • International advisory board: PhytoMab/Songan University (Korea), Member
  • Advisory Board, GreenBio Pharmaceutical, Member

Service

  • National Science Fundation (NSF), Panelist (2010 - Present)
  • National Institutes of Health (NIH), Panelist (2008 - Present)
  • Canadian Ministry of agriculture research grant peer reviewer (2006 - Present)
  • NIH Peer Review: Gene and Drug Delivery, Panelist (2015)
  • Czech Science Foundation, Grant reviewer (2015)
  • Natural Sciences and Engineering Research Council of Canada (NSERC), Grant reviewer (2015)
  • NIH Peer Review: Cell, computational and Molecular Biology : 2015/10 ZRG1 IMST-J (15), Panelist (2015)
  • BioMed Research International, Special Issue: Plant-Made Biologics, Lead Editor (2013 - 2014)
  • IJMS, Special Issue: Protein Engineering, Editor (2014-2015)